Convergent Research Thrust Areas
All engineering research in ATP-Bio is aimed at eliminating or mitigating the three enemies of biopreservation: ice formation, cryoprotective agent (CPA) toxicity, and slow and/or non-uniform rewarming.
Thrust Area 1: Biological Engineering
We aim to develop new CPAs and CPA delivery, uptake, and removal systems to reduce or eliminate CPA toxicity. This will involve engineering at the molecular, genetic/cellular, and tissue/organ levels.
Shannon Tessier (MGH)
Thrust Area 1 Co-Lead
Martin Yarmush (MGH)
Thrust Area 1 Co-Lead
Thrust Area 2: Multi-scale Thermodynamics of Water
We aim to mitigate or eliminate ice formation during cooling of biological systems down to -140°C.
Rebecca Sandlin (MGH)
Thrust Area 2 Co-Lead
Boris Rubinsky (UCB)
Thrust Area 2 Co-Lead
Thrust Area 3: Rapid and Uniform Warming
We aim to eliminate spontaneous ice formation and thermal cracking that occurs when cryopreserved biological systems are warmed.
John Bischof (UMN)
Thrust Area 3 Co-Lead
Guillermo Aguilar (TAMU)
Thrust Area 3 Co-Lead
Testbeds
Each of our testbeds connects to a distinct market segment. We aim to produce biopreservation technologies that will accelerate the growth of each of these market segments via new products and vastly improved storage and distribution of products.
Berk Usta (MGH)
Cell Testbed Lead
Kevin Healy (UCB)
MPS Testbed Lead
Erik Finger (UMN)
Organ Testbed Co-Lead
Basak Uygun (MGH)
Organ Testbed Co-Lead
Shannon Tessier (MGH)
Organisms Testbed Lead